Abstract
ABSTRACT Linseed hydrogel (LSH) was evaluated by acute toxicity for its potential application in oral drug delivery design. White albino mice and rabbits were divided in four groups (I-IV) and different doses of LSH (1, 2 and 5 g/kg body weight) were given except to the control group (I) that was left untreated. Rabbits were monitored for eye irritation, acute dermal toxicity and primary dermal irritation, whereas, body weight, food and water consumption, hematology and clinical biochemistry, gross necropsy and histopathology of vital organs were scrutinized in mice. LSH was considered safe after eye irritation test as no adverse signs or symptoms were seen in the eye. In dermal toxicity and irritation study, skin of treated rabbits was found normal in color without any edema or erythema. After oral administration, there was no sign of any abnormalities in treated group animals (II-IV). The hematology and clinical biochemistry of treated group animals was comparable with the control group. Histopathology of vital organs has not shown any lesion or abnormalities. In the light of these outcomes, it can be concluded that LSH is not a hazardous biomaterial and could be incorporated as an excipient in oral and dermal preparations.
Highlights
Over the past few decades, enormous progress has figured out in the invention and development of biomaterials for various biomedical applications (Hoffman, 2000)
Primary dermal irritation index was calculated as 0.0 indicating the Linseed hydrogel (LSH) as a non-irritating material to the skin
A single oral dose of LSH was given to three groups of male albino mice (Table I)
Summary
Over the past few decades, enormous progress has figured out in the invention and development of biomaterials for various biomedical applications (Hoffman, 2000). Polysaccharides based polymeric biomaterials have drawn appreciable attention of the biomedical scientists due to their biocompatibility (Dang, Leong, 2006), biodegradability (Jain, Gupta, Jain, 2007), bioavailability (Mizrahy, Peer, 2012), ease and versatility in drug designing and development (Zhang, Wardwell, Bader, 2013; Hussain et al, 2011; Hussain et al, 2009). These properties make such naturally occurring polysaccharides an integral part of many drug delivery systems (Iqbal et al, 2011; Xu et al, 2015; Muhammad et al, 2016; Ashraf et al, 2017). Linseed is rich in polysaccharides which are present in the seed coat and mainly composed of rhamnogalacturonan and
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