ACUTE TOXICITY STUDY OF A NEW ANTIPARASITIC AGENT

Abstract

The search and introduction of new pharmacological agents aimed at their safe use in therapeutic and prophylactic measures in the fight against helminthiases of birds remains relevant today. The purpose of this work was to study the acute oral toxicity of the new anthelmintic agent "K-55" on white mice. The compound is a black powder soluble in water. The drug was administered orally to mice using a clubshaped needle at doses of 500, 750, 1000 and 2000 mg/kg. The results of studying the acute toxicity of the new pharmacological agent "K-55" on white mice showed that with a single oral administration of it in test doses from 500 to 2000 mg/kg during the study, the death of experimental animals and morphological changes in the structures of organs not detected. After 14 days, the clinic of the animals of the experimental groups did not differ from the control group. Appetite disturbance, motor activity and toxic effect were not observed. According to GOST 12.1.007- 76 "Classification and general requirements for toxicological safety", according to the parameters of acute toxicity, it belongs to the 3rd hazard category (moderately hazardous substances).