Abstract
Introduction: The moringa oleifera (MO) plant is popularly known as the “miracle tree”. The uses of MO leaf extract in controlling high blood pressure and as a food supplement with high nutritional value have been documented scientifically. Some studies have also shown that dosages appear to be safe from tested toxicity but a relative increase such as 3-4 times the recommended doses is known to cause genotoxic damage. However, there is a paucity of human evidence of the potency of MO presently, most studies use animal models such as rats and ethanol extract. Objective: The study aims to assess the acute toxicity lethal and sublethal doses (LD50) of MO using Swiss albino mice and its phytochemical constituents in our locality where consumption is very high. Methods: The ethanol extraction method was used to obtain the concentrates of 100 g, and thirty (30) adult mice (30 - 40g) were used for Acute Toxicity (LD50). Phytochemical analyses were carried out to determine the major Bio-constituents. Result: Showed that LD50 of 3900 mg/kg produced death in mice. Piloerection amongst others and weight gain were observed in sublethal doses. Carbohydrates (36.6%), Calcium, Phenol, Ascorbic acid, and Methyl Octadecenoate (30%) recorded the highest constituents. Conclusion: it is safe to consume MO to promote health in the right doses.
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
