Abstract
N-(2,3-Epoxy-propyl)-phthalimide (EPP) was tested for its oral LD50, its ability to cause ocular and dermal irritation in rabbits, and its ability to sensitize guinea pigs. The single-dose rat oral LD50 was found to be 4.7 g/kg. This chemical was slightly irritating to the rabbit skin, moderately irritating to the rabbit eye without a washout, and mildly, transiently irritating to the rabbit eye with a washout 4 sec after instillation. It did not induce a sensitization reaction in guinea pigs after 10 intracutaneous injections, although this regimen did induce a very mild irritation evident after the eighth injection. These data were interpreted to indicate that EPP did not represent a substantial acute toxic risk.
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