Abstract
The acute toxicity of aflatoxins B 1, M 1 and M 2 in one-day-old Pekin ducklings was estimated to be 12, 16 and 61·4 μg/duckling. Single doses of each of the three aflatoxins produced similar liver lesions. Whereas a high dose produced extensive haemorrhagic necrosis with little or no bile-duct proliferation, an intermediate dose produced slight bile-duct proliferation and varying degrees of hepatocellular necrosis and a low dose caused considerable bile-duct proliferation and extensive degenerative changes in liver cells. Renal congestion at low doses of M 1 and M 2 was accompanied by degenerative changes (vacuolation) of the convoluted tubules but frank necrosis was only seen with M 1. Aflatoxin B 1, even in a high dose, induced only slight degenerative changes of the tubules. None of the aflatoxins produced glomerular damage.
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