Abstract
The effects of 2,3,7,8-tetrachlorodi-benzo-p-dioxin (TCDD) on adult male mink were assessed. TCDD was administered as a single oral dose (0, 2.5, 5.0, and 7.5 μg/kg body weight) and the mink observed for 28 days. There was a dose dependent decrease in feed consumption with corresponding body weight loss. Gross necropsy revealed mottling and discoloration of the liver, spleen, and kidneys. In mink exposed to higher doses of TCDD, brain, kidneys, heart, and thyroid and adrenal glands were enlarged when expressed as a percent of body weight. Hematologic and thyroid hormone measurements in surviving animals revealed no alterations resulting from TCDD exposure. A 28-day LD50 value of 4.2 μg/kg body weight was calculated. These results indicate that mink are among the most sensitive species to TCDD and that they can serve as a valuable model to study the impact of environmental dioxins on carnivorous mammalian species.
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