Abstract
Elevated prolactin levels suppress pulsatile release of GnRH from the hypothalamus, with a consequent reduction in pulsatile LH secretion from the pituitary. In this paper, the authors showed in mice that kisspeptin neurons located in the arcuate nucleus (ARC) respond to prolactin and conditional knockout of the prolactin receptor specifically in ARC kisspeptin neurons prevented prolactin-induced suppression of LH secretion.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have