Abstract
BackgroundThe theory of Chinese medicine believes rage harms normal liver function, namely ’raged impairing liver' in short. The purpose of this study is to investigate the impact of acute stress on liver lipid metabolism in rats.Methods and resultsComparison of liver function indicators, serum lipid level of rats under acute stress and normal rats, as well as detection of liver tissue in the SR - BI, ABCG5 and ABCG8 protein and gene expression changes. Acute stressed rats had shown a lower serum levels of albumin (P<0.01), HDL- cholesterol (P<0.01) than normal rats, with higher serum levels of globulin (P<0.01) and LDL-cholesterol (P<0.05). Acute stressed rat’s liver tissue exhibited a lower protein expression of ABCG5 (P<0.05), ABCG8 (P<0.01) and a higher level of SR-BI (P<0.05), compared with to normal rats. Furthermore, liver gene expression of ABCG5 (P<0.01) and ABCG8 (P<0.05) were lower in acute stressed rats than in normal rats, while SR-BI was higher in acute stressed rats than in normal rats (P<0.01).ConclusionsAcute stress had a direct influence on rat’s liver lipid metabolism.
Highlights
The theory of Chinese medicine believes rage harms normal liver function, namely ’raged impairing liver' in short
Acute stress affects lipid metabolism in rats We examined the effects of acute stress on expression levels of liver ABCG5, ABCG8 and scavenger receptor- BI (SR-BI) using western blotting
We found serum ALB level was lower in the model group, with higher GLB, low-density lipoprotein cholesterol (LDL-C) and lower high-density lipoprotein cholesterol (HDL-C), demonstrated acute stress may damage rat’s liver, leading to a reduction in ALB production, an increase in GLB
Summary
The theory of Chinese medicine believes rage harms normal liver function, namely ’raged impairing liver' in short. The purpose of this study is to investigate the impact of acute stress on liver lipid metabolism in rats. Stress has shown to play an important role in the onset of cardiovascular diseases, immunological disorders and pathophysiological consequences of normal aging [2,3,4]. Stress had been shown that will inhibit metabolic function, such as lipid elimination and glycometabolism [5,6]. The theory Chinese Medicine believes rage harms liver function [7]. Acute stress causes rage, so acute stress may individually damages the liver. The liver is a crucial organ that facilitate lipid metabolism, including cholesterol metabolism and it is meaningful to study acute stress’s effect on lipid metabolism in rats.
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