Acute stress persistently alters instrumental motivation without affecting appetitive Pavlovian conditioning, extinction, or contextual renewal

Abstract

In two experiments, we adapted the stress-enhanced fear learning approach to evaluate the persistent effects of acute stress on appetitive learning and motivation in adult male Long Evans rats. In Experiment 1, we found that exposure to a battery of footshocks in one context had no effect on the acquisition, extinction, or contextual renewal of an appetitive Pavlovian discrimination in different contexts. However, when rats were subsequently trained to respond on a progressive ratio instrumental schedule, rats with a history of shock showed lower response rates and progressive ratio break points. Extinction of the shock-associated context had little effect on progressive ratio responding. In Experiment 2, we replicated this instrumental responding deficit with a continuous reinforcement schedule when the Pavlovian phases did not intervene in the time between shock and instrumental testing. Our findings here demonstrate that highly stressful acute experiences produce long-lasting deficits in instrumental motivation for food in male rats.