Abstract
Clopidogrel and ticlopidine are agents that irreversibly inhibit adenosine diphosphate (ADP)–induced platelet aggregation.[1][1] Interaction of ADP with the P2Y1 receptor of the platelet induces platelet shape change, reversible aggregation, initial glycoprotein IIb/IIIa activation, phospholipase
Highlights
We report our experience with a 39-year-old woman with traumatic bilateral internal carotid artery dissections following a traffic crash
A platelet function assay (PFA-100, Dade Behring, Deerfield, Ill) using platelet closure time demonstrated a value above 300 seconds following activation by 10 g of epinephrine
Partial reversal of clopidogrel was attempted by intravenous administration of 25 mg of methyl prednisolone
Summary
We report our experience with a 39-year-old woman with traumatic bilateral internal carotid artery dissections following a traffic crash. A platelet function assay (PFA-100, Dade Behring, Deerfield, Ill) using platelet closure time demonstrated a value above 300 seconds (the maximum measurable value by the instrument) following activation by 10 g of epinephrine.
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