Acute responses of regional vascular conductance to oral ingestion of fructose in healthy young humans.

Masako Y Endo,Chizuko Fujihara,Yoshiyuki Fukuoka,Kouhei Eguchi,Chinami Yamazaki,Akira Miura,Hideaki Kashima,Yoshiyuki Fukuba

doi:10.1186/1880-6805-33-11

Abstract

BackgroundRecently, it was reported in healthy young subjects that fructose containing drinks increased blood pressure acutely, without any apparent change in total vascular conductance (TVC). However, because it is well known that the splanchnic vasculature is dilated by oral fructose ingestion, it is assumed to be the concomitant vasoconstriction in other peripheral region(s) that is responsible for this finding. Thus, the purpose of this study was to determine the acute response of regional VC to oral fructose ingestion in young healthy humans.ResultsIn 12 healthy young subjects, mean arterial blood pressure (MAP), heart rate, cardiac output, and blood flow (BF) in the superior mesenteric (SMA), brachial (BA), and popliteal (PA) arteries, in addition to forearm skin BF, were measured continuously for 2 h after ingestion of 400 ml fructose solution (containing 50 g fructose). Regional VC was calculated as BF/MAP. MAP increased for 120 min after fructose ingestion without any change in TVC. While VC in the SMA was elevated after ingestion, VC in BA and PA and forearm skin decreased.ConclusionsWhile TVC was apparently unchanged during the 2 h after fructose ingestion, there were coincident changes in regional VCs in the peripheral circulation, but no net change in TVC.

Highlights

It was reported in healthy young subjects that fructose containing drinks increased blood pressure acutely, without any apparent change in total vascular conductance (TVC)
Even in healthy young subjects, Brown et al [7] showed that oral consumption of a 50-g pure fructose-containing drink rapidly increased blood pressure (BP), which was sustained for at least a few hours, whereas there was no comparable effect after consumption of either a glucosecontaining drink or water [7]
All subjects were informed of the purpose, protocol, and risks associated with the procedures before giving written informed consent to participate in the study, which was approved by the local Ethics Committee of Hiroshima and was conducted in accordance with the Declaration of Helsinki

Summary

Introduction

It was reported in healthy young subjects that fructose containing drinks increased blood pressure acutely, without any apparent change in total vascular conductance (TVC). Even in healthy young subjects, Brown et al [7] showed that oral consumption of a 50-g pure fructose-containing drink rapidly increased BP, which was sustained for at least a few hours, whereas there was no comparable effect after consumption of either a glucosecontaining drink or water [7]. They suggested that fructosespecific acute elevations in BP were mainly mediated not by a decreased peripheral vascular response (that is, no change in total vascular conductance, TVC), but by a sustained elevation of cardiac output (CO). We did this study as a pilot to reconfirm the results by Brown et al [7], including the simultaneous measurements of peripheral VCs in several targeted arteries with our technique (that is, pulsed Doppler ultrasound sonography)

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