Abstract
Background: Aerobic exercise has been shown to impart anti-inflammatory effects partly through increased secretion of interleukin-6 (IL-6). Still unclear, however, is whether resistance exercise (RE) also enhances IL-6 secretion. Objective: The present study aimed to examine the effect of RE, performed at varying volume loads (VL), on plasma IL-6. Methods: Ten subjects (seven males and three females: age 37.9 ± 11.4 years; height 170.81 ± 11.16 cm; weight 71.36 ± 11.26 Kg.) participated in three randomized RE protocols: high VL (HVL) (5 sets x 20 repetitions at 45% 1-repetition maximum (1-RM), medium VL (MVL) (3x12 at 75% 1-RM), and low VL (LVL) (2x4 at 90% 1-RM) each separated by 96 hours. Capillary blood for IL-6 measurements was drawn immediately pre-exercise, immediately post-exercise, and 1- and 2-hours post-exercise. Results: There were no significant differences in plasma IL-6 between exercise condition (LVL, MVL, HVL) or at any time point (p=0.422 and p=0.870, respectively). Conclusion: Plasma IL-6 levels are not acutely sensitive to RE, regardless of volume load; therefore, any reported anti-inflammatory effect of RE appears to operate outside of the exercise-induced IL-6 pathway.
Highlights
Regular exercise reduces the risk against all-cause of mortality primarily by protecting against cardiovascular disease, type 2 diabetes mellitus, and cancer (Chen, Apostolakis, & Lip, 2014; Reihmane & Dela, 2014)
While we hypothesized that the MVL resistance exercise (RE) protocol would elicit the highest post-exercise plasma IL-6 concentrations, our primary findings show that neither low-volume load (LVL), high-volume load (HVL), nor MVL RE elicited a change in plasma IL-6 levels
rate of perceived exertion (RPE) of the HVL and MVL protocols was greater than LVL, which correlates with Phillips et al (2010), who found that RPE was greater in their HVL protocol compared to their LVL protocol
Summary
Regular exercise reduces the risk against all-cause of mortality primarily by protecting against cardiovascular disease, type 2 diabetes mellitus, and cancer (Chen, Apostolakis, & Lip, 2014; Reihmane & Dela, 2014). A common sign of these diseases is chronic low-grade systemic inflammation (CLGSI), a condition mediated by several pro-inflammatory cytokines. One of these cytokines, interleukin-6 (IL-6), is considered to be the major inducer of acute-phase proteins (APP) gene expression, since it, either alone or by enhancing the effects of other cytokines, induces virtually all APPs (Chen et al, 2014; Reihmane & Dela, 2014; Simpson, Hammacher, Smith, Matthews, & Ward, 1997). Conclusion: Plasma IL-6 levels are not acutely sensitive to RE, regardless of volume load; any reported anti-inflammatory effect of RE appears to operate outside of the exercise-induced IL-6 pathway
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: International Journal of Kinesiology and Sports Science
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
