Abstract
In an in-hospital study, 3 out of 5 patients with essential hypertension on continuous chlorthalidone treatment developed reversible renal insufficiency when chlorthalidone was replaced by tienilic acid. In a control group of 6 patients, tienilic acid after placebo was not followed by renal insufficiency. Since the urinary uric acid concentration and the uric acid/creatinine ratio was not higher in the patients who developed renal insufficiency than in the control group, the drug interaction probably cannot be explained by uric acid nephropathy.
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