Abstract
SummaryThis study evaluates the correlation between renal structural alterations and renal functional impairment 24 hr after induction of oliguric acute renal failure in the rat by intramuscular glycerol injection. The major structural alterations were renal tubular epithelial cell necrosis and plugging of tubular lumens; these were graded as to severity in a blind fashion. Renal functional impairment was estimated by blood urea nitrogen (BUN) measurements. The rats were studied under conditions of varied dietary sodium content resulting in different levels of activity of the renin-angiotensin system which is known to be involved in the pathophysiology of this disorder. Renal structural alterations were severe in the low dietary sodium group, modest in the normal dietary sodium group and least in the high dietary sodium group. Renal functional impairment followed a similar pattern, BUN: low dietary sodium group 165 ± 21 mg%, normal dietary sodium group 75 ± 14 mg%, high dietary sodium group 43 ± 6 mg%. Wh...
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Schedule a callMore From: Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)
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