Acute (rat and mouse) and short-term (rat) toxicitystudies on isooctyl isodecyl nylonate

Abstract

Isooctyl isodecyl nylonate was not lethal when given to rats orally or intraperitoneallyor to mice intraperitoneally in a single dose of up to 10 g/kg. The oral LD50 in mice was 8–10 g/kg.Rats were fed dietary levels of 0 (control), 125, 500, 2000 or 8000 ppm for 105 days. Therewere no effects on growth, food consumption, haematology or serum chemistry and no histopathological changes were seen in the treated animals. Kidney weights were significantly elevated in males in the 2000 and 8000 ppm groups and this increase was associated with an increased urinary cell excretion. Liver weight was increased in animals of the 8000 ppm group. The association of this increase with increased urinary ascorbic-acid excretion and increased activity of liver-microsomal processing enzymes is described. Adrenal and ovary weights were increased in females fed the highest dietary level.The level of nylonate at which no untoward effect was detected was 500 ppm which isapproximately equivalent to an intake of 25 mg/kg/day.