Abstract
Rabbits were irradiated with 250 to 1600 r Co60 gamma rays, and the degradation and distribution of albumin in the ani mals were investigated by means of I131-labeled albumin injected intravenously after irradiation. The half life of the labeled albumin was found to be inversely proportional to the radiation dose, indicating an increased albumin catabolism and leakage through the gastrointestinal wall. The excessive excretion of radioactivity in the rabbit irradiated with 1200 r indicates partial restitution of the re- absorption capacity of the intestine. It is concluded that the epithelium and capillaries of the gastrointestinal tract constitute the most sensitive system in acute radiation injury. (D.L.C.)
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