Acute psychological stress alerts the adaptive immune response: Stress-induced mobilization of effector T cells

Abstract

Influences of psychological stress on the acquired immune system have not consequently been investigated. We found acute psychological stress to cause an increase in CD56 + and CCR5 + effector T cells in the peripheral blood of healthy human subjects ( N = 22), while skin-homing CLA+ T cells decreased. At the same time, we observed a stress-induced decrease in CD45RA+/CCR7+ naive and CD45RA−/CCR7+ central memory T cells, while CD45RA−/CCR7− effector memory and CD45RA+/CCR7− terminally differentiated T cells increased. This T cell redistribution translated into an increase in T cells expressing perforin/granzyme B and in Epstein-Barr virus-specific, cytomegalovirus-specific and influenza virus-specific CD8 + T cells. Thus, acute stress seems to promote the retention of less mature T cells within lymphoid tissue or skin while effector-type T cells are mobilized into the blood in order to be able to rapidly migrate into peripheral tissues.