Abstract
Transrectal ultrasound-guided prostate biopsies (TRUSBx) are common and increasingly performed procedure. As this procedure can be complicated by infections, antibiotic prophylaxis is widely used around the world to minimize these complications, but there is no consensus on the most appropriate prophylaxis regimen. A total number of 412 patients who were referred fo TRUSBx, was devided randomely into two groups. Group 1 received routine antibiotic prophylaxis and Group 2 did not received Amikacin. Other premedications in both groups include ciprofloxacin, metronidazole, ceftazidime and povodine iodine gel. 2 days after biopsy, all patients were investigated about significant fever(e�38°C). febrile patients were referred to urology clinic for further evaluation about acute prostatitis or septicemia. There was 210 patients in group A and 202 patients in group B. No significant difference was detected in mean age, prostatic volume, serum PSA level, re-biopsy rate and pathology report between two groups. Acute prostatitis was developed in 2 patients (0.9) in group A and 1 patient (0.5) in group B that was not statistically significant.(P>0.05) Removing amikacin from ciprofloxacin-based antibiotic prophylaxis along with local povodine iodine would not put our patients in increased risk for infectious complications after TRUSBx. © 2016, Oriental Scientific Publishing Company. All rights reserved.
Highlights
Transrectal ultrasound-guided prostate biopsy (TRUSBx) is currently the gold-standard method for diagnosis prostate cancer1
Extended core biopsy technique provided taking at least 10 core biopsies transrectally, so Infectious complications could occure after TRUSBx, including fever, UTI, acute prostatitis, epididymo-orchitis and even life-threatening septicemia8,7
There was no significant difference in mean age as well as mean prostate volume and mean serum prostatic specific antigen (PSA) level between two groups.(P>0.05)
Summary
Transrectal ultrasound-guided prostate biopsy (TRUSBx) is currently the gold-standard method for diagnosis prostate cancer. Transrectal ultrasound-guided prostate biopsy (TRUSBx) is currently the gold-standard method for diagnosis prostate cancer1 Using this test, early detection of prostate cancer have been possible and this has a role in decreasing death rates from prostate cancer in recent years. The most common indication for TRUSBx is elevated serum prostatic specific antigen (PSA) level. Since using PSA as a marker in early detection of prostate cancer, the number of TRUSguided biopsies have dramatically increases. Antibiotic prophylaxis before TRUSBx had been shown to reduce the infection rate significantly. For this reasons, antibiotic prophylaxis is routinely prescribed
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