Abstract
The total adenine nucleotide content of the mitochondrial matrix increases 3–4-fold within a few hours of birth in rat liver. This provides a mechanism for the acute postnatal regulation of pyruvate carboxylase, which is located in the matrix compartment and which requires ATP as a substrate. The sudden increase in pyruvate carboxylase activity is proposed to account for a rapid 4–5-fold increase in the gluconeogenic rate of the newborn rat.
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