Abstract
Legionnaires’ disease is a severe form of lung infection caused by bacteria belonging to the genus Legionella. The disease severity depends on both host immunity and L. pneumophila virulence. The objective of this study was to describe the pathological spectrum of acute pneumonia caused by a virulent clinical isolate of L. pneumophila serogroup 1, sequence type 62. In A/JOlaHsd mice, we compared two infectious doses, namely, 104 and 106 CFU, and their impact on the mouse status, bacterial clearance, lung pathology, and blood count parameters was studied. Acute pneumonia resembling Legionnaires’ disease has been described in detail.
Highlights
We report on a highly virulent clinical isolate from a patient who presented with severe acute pneumonia and septic shock with the etiological agent identified as L. pneumophila serogroup (Sg) 1, sequence type (ST) 62, which is in the top six strains internationally that cause disease [15]
A 64-year-old man presented to the pulmonology clinic with exacerbated chronic obstructive pulmonary disease (COPD)
L. pneumophila Sg 1, ST 62, monoclonal antibody (MAb) Knoxville is a highly virulent sequencing type causing a severe infection in susceptible human hosts, as suggested by the case report described
Summary
-called intracellular bacteria, have acquired a complex and intricate ability to “hide” in mammalian cells, such as macrophages, thereby preventing antibiotics from destroying hidden pathogens and further increasing the challenges of therapy [3]
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