Abstract
The HELLP syndrome is a severe form of preeclampsia that compromises pregnancy. The pathophysiology is largely unknown, although endothelial cell activation leading to thrombotic microangiopathy is suggested. Von Willebrand Factor (vWF) mediates platelet binding to the vessel wall by conversion of the vWF A1-domain into a platelet glycoprotein Ib (GpIb)-binding conformation. AU/vWFa-11, a llama-derived nanobody, which preferentially recognizes this GpIb-binding conformation in vWF, was used to assess activated vWF.
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