Acute Phase Proteins, Trace Elements and Cytokines Expression as A Diagnostic and Prognostic Biomarker in Diseased Camel

Abstract

The present study was carried out to evaluate the diagnostic value of inflammatory biomarkers on diseased camels via exploring the possible effects on oxidants and antioxidants status in addition to characterizing the profiles of acute phase proteins and inflammatory cytokines. Forty-eight adult male and female dromedary camels (Camelus dromedaries) were examined, according to general health conditions, clinical and laboratory diagnosis they were split into 3 groups. Group 1: Included 20 apparently healthy camels act as a control group, Group 2: Included 12 camels suffered from trypanosomiasis, Group 3: Included 16 camels suffered from mange. Our results revealed that the mean values of copper and zinc were significantly decreased with statistical elevation of MDA and statistical lowering of catalase and total antioxidant capacity in cases of trypanosomiasis and mange compared to apparently clinically healthy camels (P value <0.05), there is a pearson negative correlation between copper and MDA (r=-0.6; P<0.05) in diseased camels, The mean values of acute phase proteins (haptoglobin, ceruloplasmin and serum amyloid A) and inflammatory cytokines (IL-1, IL-6, IL-10 and TNF-α) were significantly elevated in diseased camels at (Trypanosomiasis and mange) than apparently clinically healthy camels (P value <0.05).