Acute phase proteins levels (C3 , C4 and hsCRP) in type 2 diabetes patients

Abstract

Diabetes mellitus is one of public health problem in world. Type 2 diabetes millitus (T2DM) which resistance cell to insulin. more inflammation occur in Patients with T2DM because of elevation of inflammatory marker like C3, C4 & hsCRP. This study was aimed to detect the level of acute phase reactant proteins (C3 , C4 and hsCRP) in T2DM patients. Blood samples were collected from 60 patients with T2DM and control group was included 30 healthy donors. C3, C4 & hsCRP levels were estimated for all samples. Samples were grouped according to complications of patients. The results showed that there was a significant increase in C3 level for patients with T2DM (199.0 mg/dl) compared to control group (135.4 mg /dl) while C4 level for T2DM (27.25 mg/dl) showed no significant change compared to control group( 30.04mg/dl). C3 level of patients under heart disease (199.6 mg/dl ), patients under thyroid disease (230.4 mg/dl) and patients without any disease (188.1 mg/dl) recorded significant elevation compared with control group (135.4 mg /dl) but C4 level did not show any significant change for all groups. hsCRP level recorded significant increasing in all study groups as fallowing : in all included patients (2.506 mg/L), T2DM patients with heart disease (2.238 mg/L),T2DM patients with thyroid disease (2.433 mg/L) and T2DM patients without any disease (2.20mg/L), The conclusion of this study was the inflammation process associated with T2DM where inflammatory markers (C3 and hsCRP) elevated.