Abstract
Ionizing radiations are well recognised causes of leukaemia in man, cases having been recorded following irradiation in a variety of circumstances. Thus, leukaemia has been noted among atomic bomb survivors in Japan (Lange, Moloney and Yamawaki, 1954; Moloney, 1955; Heyssel, Brill, Woodbury, Nishimura, Chose and Hoshino, 1960); in radiologists occupationally exposed (March, 1944, 1950; Ulrich, 1946); in patients, following radiodiagnostic procedures (Stewarth, Webb and Hewitt, 1956); and in particular in patients following radiotherapy. The first case following therapeutic irradiation was described by Merklen and Wolf (1925) as a complication of radiotherapy of a fibromatous uterus. Since then leukaemia has been described following radiotherapy of ankylosing spondylitis (van Swaay, 1955; Abbatt and Lea, 1956; Court Brown and Abbatt, 1955; Court Brown and Doll, 1957; Cooper and Steinbeck, 1958; Graham, 1960; Silberberg, Frohman and Duff, 1960), thymic enlargement in infancy (Simpson, Hempelmann and Fuller,...
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