Abstract
Purpose: The aim of the study was to elucidate, in rats, whether females or the acute administration of estradiol to males has a local or systemic effect in an experimental model of acute pancreatitis. This was prompted by our previous findings of females having a better response following injury of both the immune system and the Selye axis. Methods: In 44 male and female Wistar rats, three groups were examined. There were 16 control males (CM), 18 estradiol males (EM) and 10 females (F). Under thiopental anesthesia a short-term (20 min), closed duodenal loop experimental model was constructed to induced AP. The CM and F groups were subjected to a subcutaneous injection of peanut oil 30 mins prior to test. The EM rats were injected with 50 microgram/kg estradiol benzoate 30 min prior to the test. Twenty-four hours after injections, the rats were sacrificed and a histopathologic score of the pancreas were obtained in the three groups. Results: The mortality rate was significantly diminished in the F group (12.5%) compared to the CM (30%) and EM (28%) groups. Glucose and amylase levels were lower in the F group as compared to the CM and EM groups. Lipase level was significantly augmented post-test in the three series but primarily in the F rats. Transaminase and LDH were elevated in the three groups. The histological score of the pancreas (i.e. edema, necrosis and leukocyte infiltration) were lowered in the EM and F groups as compared to the CM group. Conclusions: Female sex or the acute administration of estradiol to male rats is associated with a significant reduction of AP lesions. It has been shown that acute estradiol administration exerts an anti-inflammatory effect on induced closed duodenal loop AP. The mechanism is through potentiation of the normal cytoprotective effects elicited by endogenous secretin possibly by an enhanced response to injury of the immunologic system and the Selye stress axis.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
