Abstract
Purpose: Synovitis-associated pain is an important aspect of arthritis pathology. Several inflammatory mediators released by the synovium have been implicated in the regulation of pain, including S100A8 and S100A9 which may regulate pain either via direct stimulation of TLR4 on the nerve endings in the synovium or via stimulation of the dorsal root ganglia (DRG), thereby enabling an increased phagocyte infiltration, which may cause sensitization. We aimed to elucidate the role of S100A9 in the pain response after induction of synovitis using streptococcal cell walls (SCW), a known TLR2 ligand, as a trigger, comparing S100A9-/- mice and their WT controls.
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