Abstract
Systematic documentation of local health tradition related knowledge is important for validating and preserving medicinal heritage of any place. Lepidagathis keralensis Madhus. & NP Singh. is a species belonging to Acanthaceae family It is a perennial, prostrate, woody herb tenaciously attached to hard laterite soil. It is used by traditional practitioners of North Malabar for various ailments. Safety is of primary importance as far as any drug is concerned. No scientific data is available on the safety profile of this drug. Acute Oral toxicity study is the foremost step among toxicity studies. Hence this study was taken up. Aim & objective: To assess the Acute Oral Toxicity of water extract of Lepidagathis keralensis Madhus. & NP Singh. Materials and methods: Aqueous extract of the drug was orally administered in Wistar albino rats at different dose levels and various parameters for signs and symptoms of gross behavioural and physical changes starting from 30 minutes to 48 hours at various intervals were observed. Results and observations: The drug did not produce any signs of toxicity and mortality upto the dose of 2000 mg/kg in rats. Hence this drug which is extensively in use among traditional practitioners can be further studied and brought forward to main stream.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
