Abstract
The current study described the synthesis and the in vivo acute oral toxicity evaluations in Sprague Dawley rats. The compounds were characterized by elemental analyses, LC-MS, FTIR, 1H NMR, 13C NMR and UV-visible spectroscopy. In the acute toxicity study, a single administration of the compounds was performed orally to the rats at the single doses of 2000 mg/kg and they were then monitored for possible side effects, mortality or behavioral changes up to 14 days. The serum level of aspartate (AST), alanine aminotransferases (ALT), alkaline phosphate (ALP), triglyceride, high density lipoprotein (HDL), immunoglobulins (GAM) and the C-reactive proteins did not significantly change. The hematological indices white blood cells (WBC), haematocrit (HCT), red blood cells (RBC), mean corpuscular volume (MCV), mean corpuscular haemoglobin concentration (MCHC), and mean corpuscular hemoglobin (MCH) were within the normal range. The renal function indices examined were also within the reference range. Generally, the compounds exhibited low toxic effects as required for further in vivo therapeutic studies.
Highlights
Zinc has been shown to play an important role in wound healing, proper functioning of mucosal cells, reduction of reactive oxygen species (ROS) [1] and as a cofactor for metallo-enzymes [2]
Several studies were performed to determine the mechanisms for zinc balance and the effects of zinc excess on iron metabolism [3] with much emphasis on small molecular weight metal binding proteins [4]
The animals treated with the zinc complexes for two weeks had manifested an increase in body weight slightly above the animals in the control group (Figure 1)
Summary
Zinc has been shown to play an important role in wound healing, proper functioning of mucosal cells, reduction of reactive oxygen species (ROS) [1] and as a cofactor for metallo-enzymes [2]. The interaction of zinc ions with certain Schiff base ligands has been studied due to their relevance in bio inorganic chemistry. They form carbon-nitrogen bonds [5], which make them important intermediates in a number of enzymatic reactions [6,7,8]. The activities of various ligands were reported to have increased upon coordination with the metal ions; studies on novel metal-based compounds with therapeutic potential became an area of intense investigation in biomedical and inorganic chemistry [9,10,11,12]. Complexes derived from some 1-(2-salicylaldiminoethyl) piperazine Schiff bases
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