Abstract
Hydrocotyle sibthorpioides (Family: Apiaceae) is a medicinal plant and is been a part of traditional cuisine. Hence, an acute toxicity study was performed to confirm its safety profile. Female rats (n=5) were randomly divided into 5 groups. One group served as the control and the other groups were been administered with the petroleum ether, chloroform, methanolic and aqueous extract of Hydrocotyle sibthorpioides at 2000 mg/kg body weight. Blood was collected at certain intervals to measure the haematological and biochemical parameters. The vital organs were isolated and preserved for histopathological examinations. The result suggested that the LD50 of all the extracts are greater than 2000 mg/kg body weight. There was no significant change in body weight, Behaviour, Renal Function test, Liver function test and Lipid profile. In haematological evaluation, there was an increase in RBC count and haemoglobin production post administration of methanolic and aqueous extract. The study suggested that the LD50 of the plant is greater than 2000 mg/kg body weight of rats in all the extracts.
Highlights
Traditional medicines play a major role in the rural areas in-spite of the development in synthetic and semi-synthetic drugs for the treatment of different ailments
Paracelsus said “All substances are poisons; there is none which is not a poison. It is the right dose which differentiates remedy from poison” [2], it is the need of this hour is to conduct research on the safety profile of the medicinal plants
The whole plant of Hydrocotyle sibthorpioides was collected in the month of February- April 2018 from the fields of Kalabari, DistrictBiswanath chariali, PIN-784178, Assam, India and was identified as Hydrocotyl sibthorpioides Lam. by a taxonomist at Botanical Survey of India, Eastern regional centre, Shillong with Authentication letter No BSI/ERC/Tech/2018/106 dated 17/05/2018
Summary
Traditional medicines play a major role in the rural areas in-spite of the development in synthetic and semi-synthetic drugs for the treatment of different ailments. The utility of these herbal medicines is showing a tremendous shift towards the overuse [1]. Paracelsus said “All substances are poisons; there is none which is not a poison It is the right dose which differentiates remedy from poison” [2], it is the need of this hour is to conduct research on the safety profile of the medicinal plants. The in vitro and in vivo antiviral properties of H. sibthorpioides against hepatitis B virus replication have been demonstrated [10] This plant is been used in different traditional cuisines of Assam. The study was designed to explore the acute oral toxicity profile of Hydrocotyle sibthorpioides
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