Abstract
BackgroundOrganochalcogen compounds have attracted the interest of a multitude of studies for their promising Pharmacological and biological activities. The antioxidant activity and acute toxicity of an organoselenium compound, 1-(2-(2-(2-(1-aminoethyl)phenyl)diselanyl)phenyl)ethanamine (APDP) was determined in mice.MethodsMice were randomly divided into four groups, with each group comprising of seven animals. Canola oil (1ml/kg of body weight) was administered to 1st group, while 2nd, 3rd & 4th groups were administered with 10 mg/kg, 30 mg/kg & 350 mg/kg of APDP respectively. APDP was administered by Intragastric gavage as a single oral dose.ResultsThe APDP oral administration was found to be safe up to 350 mg/kg of body weight and no deaths of animals were recorded. The lethal dose 50 (LD50) for APDP was determined at 72 h and was estimated to be > 350 mg/kg. After acute treatment, all mice were sacrificed by decapitation to determine the antioxidant enzymes and lipid peroxidation values for the treated mice liver. No fluctuation in lipid peroxidation, vitamin C and non protein thiol (NPSH) levels was observed due to the administration of APDP. hepatic α-ALA-D activity, catalase (CAT), superoxide dismutase (SOD) and the biochemical parameters were evaluated. Experimental observation demonstrated that APDP protected Fe(II) induced thiobarbituric acid reactive substances (TBARS) production in liver homogenate significantly (p < 0.05). The administration of APDP (an amine-based diselenide) both in vitro and in vivo clearly demonstrated that this potential compound has no acute toxicity towards mice among all the tested parameter.ConclusionOn the basis of experimental results, it is concluded that APDP is a potential candidate as an antioxidant compound for studying pharmacological properties.
Highlights
Organochalcogen compounds have attracted the interest of a multitude of studies for their promising Pharmacological and biological activities
thiobarbituric acid reactive substances (TBARS) results in vitro experiments In TBARS experiment Iron(II) sulphate triggered a noteworthy increase in TBARS generation in mice liver homogenates (Fig. 2)
We demonstrated that liver and kidney profiles were not altered with acute treatment of binapthyl diselenide
Summary
Organochalcogen compounds have attracted the interest of a multitude of studies for their promising Pharmacological and biological activities. A dynamic equilibrium exists between the antioxidant capacity of the cell and the generation of the reactive oxygen species (ROS) in the normal conditions, which is critical for the survival as well as normal functioning of the aerobic organisms. An imbalance of the equilibrium potentially leads to damages, known as oxidative stress [1]. In the pathogenesis of various diseases and the process of accelerated aging, different biochemical, biological, and clinical studies depict the Recently, synthetic antioxidant compounds have been making their swift march but medicinal chemists have. Toxicity is attributed to the ability of the seleno-compounds to generate reactive oxygen species (ROS) and to induce oxidative stress. Various symptoms of the selenium toxicity include nail discoloration, nausea, vomiting,, loss of hair, fatigue, brittleness irritability, and foul breath odor (often described as garlic breath) [5]
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