Abstract
Background: Miller Fisher syndrome is a well-known disorder that belongs to a group of conditions with a high level of antibodies against ganglioside GQ1b. It is characterized by acute onset of ataxia, areflexia, and ophthalmoplegia. In cases of acute-onset ophthalmoplegia without ataxia, the diagnosis is more difficult; therefore, it is frequently delayed. Case Report: We report one such case of rapid onset of internal ophthalmoplegia, followed by external ophthalmoplegia. The diagnostic process was challenging, but eventually, a high level of antibodies against GQ1b confirmed the diagnosis. Because the clinical and electrophysiological findings were limited only to the presence of anti-GQ1b antibodies, a combination with a generalized form of Guillain-Barre syndrome could be excluded. Conclusion: Consequently, the patient was not treated with immunotherapy. At 4 months, the patient had made a good recovery.
Highlights
IntroductionOphthalmoplegia without ataxia, areflexia, or both has been designated as atypical Miller Fisher syndrome or acute ophthalmoplegia (AO) [1]
Conclusion: the patient was not treated with immunotherapy
Ophthalmoplegia without ataxia, areflexia, or both has been designated as atypical Miller Fisher syndrome or acute ophthalmoplegia (AO) [1]
Summary
Ophthalmoplegia without ataxia, areflexia, or both has been designated as atypical Miller Fisher syndrome or acute ophthalmoplegia (AO) [1]. In such patients, the determination of the presence of serum antibodies against ganglioside GQ1b is useful for confirming the diagnosis [2]. Miller Fisher syndrome is a well-known disorder that belongs to a group of conditions with a high level of antibodies against ganglioside GQ1b. It is characterized by acute onset of ataxia, areflexia, and ophthalmoplegia. Because the clinical and electrophysiological findings were limited only to the presence of anti-GQ1b antibodies, a combination with a generalized form of Guillain-Barre syndrome could be excluded
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