Abstract
As the market for cannabis concentrate products grows, the lack of research regarding the effects of concentrated THC and CBD becomes more glaring. The present study analyzes cannabinoid blood levels and subjective outcomes of physical sensation and affective state after ad libitum use of legal-market concentrate products. Recreational cannabis users were randomly assigned to THC- or CBD-dominant concentrate products, completing a baseline session, and an experimental mobile laboratory session consisting of timepoints before, immediately after, and one-hour after concentrate use. THC-dominant concentrates induced higher intoxication, and higher ratings of drug effect and drug liking than the CBD-dominant concentrate. Both products induced immediate feelings of elation, diminishing over the subsequent hour. Subjective outcomes in the CBD-dominant group revealed immediate decreases in tension and anxiety relative to pre-use, while the THC-dominant group only saw significant decreases in anxiety after one hour. Paranoia spiked immediately post-use in THC-dominant concentrate users, returning to baseline within an hour. Overall, the CBD-dominant concentrate invoked positive mood effects, lower intoxication and an absence of undesirable effects experienced with the THC-dominant concentrate, potentially mitigating negative effects when combined. Results support the need for further investigation into harm-reduction potential of concentrated CBD when used alone and with THC.
Highlights
As the market for cannabis concentrate products grows, the lack of research regarding the effects of concentrated THC and CBD becomes more glaring
THC plays a role in the drug reward properties underlying the abuse liability of c annabis[12]. These rewarding effects can be accompanied by subjective reports of negative affect such as increased paranoia and anxiety[13], which may worsen with high potency[14]
This study explored the acute subjective effects of two cannabis concentrate products, one a THC-dominant concentrate, containing 84.99% total THC and < 1% CBD, and the other, a CBD-dominant concentrate, containing 78.8% total CBD and 4.5% total THC
Summary
As the market for cannabis concentrate products grows, the lack of research regarding the effects of concentrated THC and CBD becomes more glaring. The present study analyzes cannabinoid blood levels and subjective outcomes of physical sensation and affective state after ad libitum use of legal-market concentrate products. THC plays a role in the drug reward properties underlying the abuse liability of c annabis[12] These rewarding effects can be accompanied by subjective reports of negative affect such as increased paranoia and anxiety[13], which may worsen with high potency[14]. Using an observational design involving self-administration of legal-market cannabis, the present study aimed to analyze cannabinoid blood levels, as well as explore subjective outcomes of physical sensation and affective state after selfadministration of legal-market concentrated products with either high THC or high CBD content. It was expected that highly concentrated THC products would produce intoxication and enhance elation (i.e. positive mood), while products containing concentrated CBD with low THC levels would be anxiolytic and less intoxicating
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