Abstract
Acute neurotoxicity following Fenpyroximate poisoning
Highlights
Fenpyroximate is a potent inhibitor of mitochondrial proton-translocating NADH-quinoneoxidoruductase [1]
Pesticide ingestion is the commonest method of nonfatal self-poisoning in Sri Lanka, being more prevalent among young males [6]
In a study of choice of poison for intentional self-poisoning in rural Sri Lanka, Eddleston et al [7] did not refer to fenpyroximate as an agent used for self-poisoning
Summary
Fenpyroximate is a potent inhibitor of mitochondrial proton-translocating NADH-quinoneoxidoruductase (complex 1) [1]. MRC grade 4 weakness was noted in both lower limbs. His upper limb and cranial nerve examination were normal. Three hours after the admission he developed transient self-limited bilateral partial ptosis and absent gag His full blood count revealed mild neutrophil leukocytosis, ESR was 12 mm/1st hr and CRP was 22 mg/dl.
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