Abstract
A simple, easily reproducible model of experimental pancreatitis is presented. By means of a catheter implanted in the pancreas, interstitial injections were performed in order to produce acute pancreatitis in guinea pigs. Injection of a sodium taurocholate solution with 50 mg/ml cephalothin produced lethal necrotizing pancreatitis similar to that obtained by the interstitial injection of the bile-salt solution incubated with trypsin. Acute pancreatitis of varying severity can be produced according to the concentration of the injected solution.
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