Acute myocardial infarction due to the unprotected left main coronary artery disease: The power of TIMI 3 flow

Abstract

Abstract Introduction Acute myocardial infarction (MI) due to unprotected left main coronary artery (ULMCA) as an infarct-related artery is a rare disease with a poor in-hospital and long-term outcome. A nearly linear correlation between post-percutaneous coronary intervention (PCI) Thrombolysis in Myocardial Infarction (TIMI) 3 grade and improved outcome is well known, however poorly reported in regard to ULMCA. Aim To assess the impact of pre- and post-procedural TIMI flow grade on outcomes of emergency PCI in men and women with acute MI due to the ULMCA disease. Material and methods Data were selected from the ongoing, nationwide, multicenter, prospective, observational registry. The study group consisted of 643 consecutive patients hospitalized during one year with acute MI with ULMCA as an infarct-related artery. Data analyzed included information from patients’ history, coronary risk factor profile, clinical presentation, therapeutic approach and adjunctive treatment. The primary end-points were in-hospital, 30-day, and 12-month mortality. Results and discussion There were 184 women and 459 men (28.6% vs. 71.4%), P Conclusions In patients with acute MI survival after ULMCA PCI depended on TIMI grade before and after the procedure.