Abstract
In recent studies it was shown that blood co-agulation and inflammation markers are raising at high geomagnetic activity; acute myocardial infarction and all his subtypes, mostly related to atheromatous plaque disruption with higher Cosmic Ray (Neutron) activity. The aim of this study was to explore AMI and ICS differences by concomitant physical conditions, accompany-ing each of these acute coronary syndromes. The data was a part of MONICA international study in Kaunas, Lithuania in years 2000-2005 (72 consecutive months). 4633 patients with AMI (2461 men) and 961 with ICS (654 men), (age up to 65) were studied. For comparison four indices of Solar (SA), three of Geomagnetic (GMA), Cosmic Ray (CRA) measured by Neutron activity imp/min. were used. Cosmophysical data were from space science institutions in the USA and Russia. Pearson correlation coefficients and their probabilities were obtained.Monthly num-ber of AMI and ICS shows different links with the physical parameters: AMI were significantly in-verse related to SA (r=-0.4, p=0.0021) and direct to CRA (Neutron) activity (r=0.23, p=0.048). ICS was not correlated with these two parameters, but show significant links to GMA (r=0.25, p=0.037). Gender differences were evident, men more close related to changes in the mentioned physical parameters.Conclusion: 1. Monthly nu- mber of AMI and ICS is different related to fluc-tuations of environmental physical parameters. 2. The described connections can affect differ-ences in the pathogenesis of these forms of Acute Coronary Insufficiency.
Highlights
Acute Coronary Syndrome includes many forms of acute coronary insufficiency
As a result a number of clinical manifestations of coronary insufficiency take place: pain (Anginal pain), cardiac arrhythmia, resulting in many cases Sudden Cardiac Death, Heart Failure etc. These symptoms can be short, resulting in angina pectoris attacks (AP), and longer and more severe, but remaining without significant myocardial damage named Intermediate Coronary Syndrome (ICS) The drop of blood supply and provoked oxygen and other vital agents disballance for a longer time often lead to necrobiosis in the area of the damaged artery with a specific additional complex of symptoms:(clinical, electrocardiographic, enzymatic) and result in later scar formation, or myocardial rupture, life threatening arrhythmias, aneurysm formation, heart failure that is considered as Acute myocardial Infarction (AMI).The ICS takes place between AP and AMI
We made some attempts compare the character of coronary lesions resulting in AMI and ICS in this relatively young population group
Summary
Acute Coronary Syndrome includes many forms of acute coronary insufficiency. Some related to clinical variants connected to myocardial ischemia-blood supply deficit due to, mostly, atherothrombosis, and coronary artery spasm, blood losses, vasculitis etc. As a result a number of clinical manifestations of coronary insufficiency take place: pain (Anginal pain), cardiac arrhythmia, resulting in many cases Sudden Cardiac Death, Heart Failure etc These symptoms can be short, resulting in angina pectoris attacks (AP), and longer and more severe, but remaining without significant myocardial damage named Intermediate Coronary Syndrome (ICS) The drop of blood supply and provoked oxygen and other vital agents disballance for a longer time (mostly more than 20 minutes) often lead to necrobiosis in the area of the damaged (culprit) artery with a specific additional complex of symptoms:(clinical, electrocardiographic, enzymatic) and result in later scar formation, or myocardial rupture, life threatening arrhythmias, aneurysm formation, heart failure that is considered as Acute myocardial Infarction (AMI).The ICS takes place between AP and AMI. The aim of this study was to explore AMI and ICS (code I21-I22 versus I20, ICD 10) by differences in concomitant environmental physical conditions: Geomagnetic, Solar and Cosmic Ray (Neutron) activity
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