Acute Myeloid Leukemia with Both Meakaryoblastic & Basophilic Differentation

Abstract

Acute myeloid leukemia with Megakaryoblastic and Basophilic differentiation and CML with concurrent Megakaryoblastic and Basophilic Blast crisis are very rare diseases with only few reported cases in the literature Diagnosis of this leukemia with two types of blasts of the same lineage can be very challenging and morphology alone is not sufficient especially when the morphology is not classical Flowcytometry and cytogenetic studies are important to establish the diagnosis Here we report a case of AML with Megakaryoblastic basophilic differentiation Positive Philadelphia chromosome by FISH