Acute (mouse and rat) and short-term (rat) toxicity studies on Carmoisine

Abstract

Acute toxicity studies in rats and mice and a short-term feeding study in rats have been carried out on Carmoisine. The acute intraperitoneal LD 50 was approximately 1 g/kg in mice and rats. Orally, doses up to 8 g/kg in mice and 10 g/kg in rats were tolerated without lethal effect. Feeding of Carmoisine to rats at dietary levels of 0·0 (control), 0·05, 0·1, 0·5 and 1·0% for 90 days evoked no adverse effect on general health, growth or food consumption and no departure from normality was seen in the haematological studies and in the liver and kidney function tests. The principal organ weight finding was an elevated relative kidney weight at 1% in females. The types and incidence of histological changes were comparable in control and test groups. A no-effect level of 0·5% Carmoisine was established in the diet of rats for 90 days, a level equivalent to 250 mg/kg/day.