Acute monocytic leukemia with KMT2A:MLLT10 transformed to AML-M7 in a pediatric patient.

Abstract

Pediatric Blood & CancerEarly View e30445 LETTER TO THE EDITOR Acute monocytic leukemia with KMT2A:MLLT10 transformed to AML-M7 in a pediatric patient Ting Li, Ting Li Department of Laboratory Medicine, Beijing Ludaopei Hospital, Beijing, ChinaSearch for more papers by this authorAixian Wang, Aixian Wang Department of Laboratory Medicine, Hebei Yanda Ludaopei Hospital, Langfang, ChinaSearch for more papers by this authorPing Wu, Ping Wu Department of Laboratory Medicine, Hebei Yanda Ludaopei Hospital, Langfang, ChinaSearch for more papers by this authorMan Chen, Man Chen Department of Laboratory Medicine, Hebei Yanda Ludaopei Hospital, Langfang, ChinaSearch for more papers by this authorHui Wang, Corresponding Author Hui Wang [email protected] orcid.org/0000-0001-8033-5924 Department of Laboratory Medicine, Hebei Yanda Ludaopei Hospital, Langfang, China Correspondence Hui Wang, Department of Laboratory Medicine, Hebei Yanda Ludaopei Hospital, Sipulan Road, Yanjiao Development Area, Langfang, 065201, China. Email: [email protected]Search for more papers by this author Ting Li, Ting Li Department of Laboratory Medicine, Beijing Ludaopei Hospital, Beijing, ChinaSearch for more papers by this authorAixian Wang, Aixian Wang Department of Laboratory Medicine, Hebei Yanda Ludaopei Hospital, Langfang, ChinaSearch for more papers by this authorPing Wu, Ping Wu Department of Laboratory Medicine, Hebei Yanda Ludaopei Hospital, Langfang, ChinaSearch for more papers by this authorMan Chen, Man Chen Department of Laboratory Medicine, Hebei Yanda Ludaopei Hospital, Langfang, ChinaSearch for more papers by this authorHui Wang, Corresponding Author Hui Wang [email protected] orcid.org/0000-0001-8033-5924 Department of Laboratory Medicine, Hebei Yanda Ludaopei Hospital, Langfang, China Correspondence Hui Wang, Department of Laboratory Medicine, Hebei Yanda Ludaopei Hospital, Sipulan Road, Yanjiao Development Area, Langfang, 065201, China. Email: [email protected]Search for more papers by this author First published: 29 May 2023 https://doi.org/10.1002/pbc.30445Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL No abstract is available for this article. REFERENCES 1Khoury JD, Solary E, Abla O, et al. The 5th edition of the World Health Organization classification of haematolymphoid tumours: myeloid and histiocytic/dendritic neoplasms. Leukemia. 2022; 36(7): 1703- 1719. 2Meyer C, Burmeister T, Groger D, et al. The MLL recombinome of acute leukemias in 2017. Leukemia. 2018; 32(2): 273- 284. 3de Rooij JD, Branstetter C, Ma J, et al. Pediatric non-Down syndrome acute megakaryoblastic leukemia is characterized by distinct genomic subsets with varying outcomes. Nat Genet. 2017; 49(3): 451- 456. 4Takita J, Motomura A, Koh K, et al. Acute megakaryoblastic leukemia in a child with the MLL-AF4 fusion gene. Eur J Haematol. 2009; 83(2): 149- 153. 5de Rooij JD, Masetti R, van den Heuvel-Eibrink MM, et al. Recurrent abnormalities can be used for risk group stratification in pediatric AMKL: a retrospective intergroup study. Blood. 2016; 127(26): 3424- 3430. 6Forlenza CJ, Zhang Y, Yao J, et al. A case of KMT2A-SEPT9 fusion-associated acute megakaryoblastic leukemia. Cold Spring Harb Mol Case Stud. 2018; 4(6):a003426. 7Qiu L, Nunez CA, Tang G, et al. A rare case of acute megakaryoblastic leukemia with t(11;17)(q23;q21) and KMT2A::MLLT6 fusion. Ann Hematol. 2022; 101(7): 1579- 1581. 8Morerio C, Rapella A, Tassano E, Rosanda C, Panarello C. MLL-MLLT10 fusion gene in pediatric acute megakaryoblastic leukemia. Leuk Res. 2005; 29(10): 1223- 1226. 9Borkhardt A, Haas OA, Strobl W, et al. A novel type of MLL/AF10 fusion transcript in a child with acute megakaryocytic leukemia (AML-M7). Leukemia. 1995; 9(10): 1796- 1797. 10Quessada J, Cuccuini W, Saultier P, Loosveld M, Harrison CJ, Lafage-Pochitaloff M. Cytogenetics of pediatric acute myeloid leukemia: a review of the current knowledge. Genes. 2021; 12(6): 924. 11Lalonde E, Rentas S, Wertheim G, et al. Clinical impact of genomic characterization of 15 patients with acute megakaryoblastic leukemia-related malignancies. Cold Spring Harb Mol Case Stud. 2021; 7(2):a005975. Early ViewOnline Version of Record before inclusion in an issuee30445 ReferencesRelatedInformation