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Abstract
Background Fatigue is a prominent, disabling symptom of MS. The prevalence and impact of fatigue highlights the need to identify approaches for its management. Purpose To examine changes in fatigue associated with an acute bout of moderate-intensity exercise in persons with multiple sclerosis (MS). Methods Females ( N = 25) with MS completed an incremental exercise test on a cycle ergometer to measure peak oxygen consumption (VO 2peak) and on a separate day completed the abbreviated Profile of Mood States (POMS) before performing 20 min of cycle ergometry at 60% VO 2peak. Participants again completed the POMS at 5, 20, and 60 min after exercise. Results There were small-to-moderate reductions in fatigue subscale scores on the POMS 20 ( d = .39) and 60 ( d = .45) min after the acute bout of exercise. Conclusion We conclude that moderate-intensity cycling exercise was associated with reductions in fatigue and might represent an appropriate stimulus for the chronic management of fatigue in persons with MS.
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