Abstract
Pyoderma gangrenosum (PG) is a rare but serious ulcerating skin disease that occurs either idiopathically or associated with various systemic diseases and malignant tumors. Although the association of PG with myeloid malignant tumors is well known, their association with lymphoid malignant tumors, especially in children is extremely rare. We present here a case of PG in a 4-year and 4 months female child, diagnosed in the Pediatrics department, which had initially evolved well with oral corticosteroid therapy and a local dermocorticoid. The development was marked 7 months after stopping corticosteroid treatment by the occurrence of acute lymphoblastic leukemia. This case of PG is presented in the intention of increasing awareness of this uncommon condition with may occurring in association with haematological malignancy. PG may precede, develop concurrently with, or follow various conditions.
Highlights
Pyoderma gangrenosum is a rare, ulcerative, cutaneous condition, which was first described in 1930, by Brun-Sting et al [1]
We present here a case of Pyoderma gangrenosum (PG) in a 4-year and 4 months female child, diagnosed in the Pediatrics department, which had initially evolved well with oral corticosteroid therapy and a local dermocorticoid
It usually occurs between the ages of 25 and 54 and rarely affects children. It is most commonly seen in patients with chronic inflammatory bowel disease, gammopathies [2] [3], rheumatoid arthritis, diabetes mellitus, myelodysplastic syndrome and myeloid leukemia
Summary
Pyoderma gangrenosum is a rare, ulcerative, cutaneous condition, which was first described in 1930, by Brun-Sting et al [1]. It usually occurs between the ages of 25 and 54 and rarely affects children. It is most commonly seen in patients with chronic inflammatory bowel disease, gammopathies [2] [3], rheumatoid arthritis, diabetes mellitus, myelodysplastic syndrome and myeloid leukemia. The evolution was marked by the occurrence of fever, pallor and bleeding manifestations, a consistent with diagnosis of acute lymphoblastic leukemia
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