Acute lung injury in patients with COVID-19 infection.

Liyang Li,Xiangdong Wang,David H Ingbar,Qihong Huang,Diane C Wang

doi:10.1002/ctm2.16

Abstract

During the 2020 Spring Festival in China, the outbreak of a novel coronavirus, named COVID‐19 by WHO, brought on a worldwide panic. According to the clinical data of infected patients, radiologic evidence of lung edema is common and deserves clinical attention. Lung edema is a manifestation of acute lung injury (ALI) and may progress to hypoxemia and potentially acute respiratory distress syndrome (ARDS). Patients diagnosed with ARDS have poorer prognosis and potentially higher mortality. Although no effective treatment is formally approved for COVID‐19 infection, support of ventilation with oxygen therapy and sometimes mechanical ventilation is often required. Treatment with systemic and/or local glucocorticoids might be helpful to alleviate the pulmonary inflammation and edema, which may decrease the development and/or consequences of ARDS. In this article, we focus on the lung edema and ALI of patients with this widely transmitted COVID‐19 infection in order to provide clinical indications and potential therapeutic targets for clinicians and researchers.

Highlights

SHORT COMMUNICATIONFunding information Operation funding of Shanghai Institute of Clinical Bioinformatics and Shanghai Engineering and Technology Center for Artificial Intelligence of Lung and Heart Diseases from Zhongshan Hospital; The National Nature Science Foundation of China, Grant/Award Number: 81873409; National Key Research and Development Program of Precision Medicine, Grant/Award Number: 2017YFC0909500
A novel coronavirus emerged in December 2019, called COVID-19, with a large number of patients in China.1,2 By March 6, 2020, there were a total of 80 710 COVID-19 cases confirmed, 482 suspected, 53 813 cured, 5737 in intensive care units, and 3045 dead in China, in addition to 17 665 confirmed, 1761 cured, and 343 dead internationally
∗The patients were summarized on the basis of the clinical characteristics from the recent studies listed in Table 2. †We summarized 3375 patients with COVID-19 infection, among whom 342 patients with intensive care unit (ICU) care and 1278 patients without ICU care had detailed clinical data

Summary

SHORT COMMUNICATION

Funding information Operation funding of Shanghai Institute of Clinical Bioinformatics and Shanghai Engineering and Technology Center for Artificial Intelligence of Lung and Heart Diseases from Zhongshan Hospital; The National Nature Science Foundation of China, Grant/Award Number: 81873409; National Key Research and Development Program of Precision Medicine, Grant/Award Number: 2017YFC0909500

Antibiotic therapy

Invasive mechanical ventilation

Chin J Diffic and Compl Cas

Findings

Chin J Clin Med