Abstract
Studies1,2,3,4,5 have shown that overexpression of genes such as superoxide dismutase, catalase, Na,K-adenosine triphosphatase, and interleukin-10 in the distal lung can protect from acute injury. All of these prior studies transduced the lungs prior to the onset of injury. In order for gene transfer to be clinically useful for acute lung injury (ALI), it will be necessary to transduce the alveolar epithelium after the onset of injury. However, the pathobiology of ALI includes alveoli filled with fluid, fibrin, inflammatory cells, and cytokines, all of which can impair alveolar gene transfer.
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