Abstract
BackgroundStill's disease is a rare systemic inflammatory disease with frequent but generally mild liver involvement. The most common cause of acute liver failure in western countries is drug-induced liver injury, while it has rarely been reported in subjects suffering from Still’s disease.Case presentationWe report a case of a young woman presenting with SD reactivation in pregnancy and acute liver failure after delivery with a possible triggering role of drug induced liver injury.ConclusionsThe prompt recognition of Still's disease reactivation allowed early introduction of steroid therapy and resolution of the clinical picture. We discuss potential factors precipitating ALF in this case, and implications for the diagnosis and management of such patients.
Highlights
Still’s disease is a rare systemic inflammatory disease with frequent but generally mild liver involvement
Acute Liver Failure (ALF) refers to a specific syndrome characterized by abnormal liver function tests, coagulopathy and altered level of consciousness due to hepatic encephalopathy (HE) in a patient with recent onset liver damage (< 26 weeks) [1]
SystemicOnset Juvenile Idiopathic Arthritis (SOJIA) is a systemic inflammatory disorder characterized by fever and arthritis, accompanied by at least one of the following: rash, generalized lymphadenopathy, hepatomegaly ± splenomegaly, and serositis (Table 1)
Summary
The prompt recognition of Still’s disease reactivation allowed early introduction of steroid therapy and resolution of the clinical picture.
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