Abstract
Coronaviruses (CoVs), including Severe Acute Respiratory Syndrome (SARS), Middle East Respiratory Syndrome (MERS), and the novel coronavirus disease-2 (SARS-CoV-2) are a group of enveloped RNA viruses that cause a severe respiratory infection which is associated with a high mortality [...].
Highlights
Coronaviruses (CoVs), including Severe Acute Respiratory Syndrome (SARS), Middle East Respiratory Syndrome (MERS), and the novel coronavirus disease-2 (SARS-CoV-2) are a group of enveloped RNA viruses that cause a severe respiratory infection which is associated with a high mortality [1,2]
There is a high incidence of acute kidney injury (AKI) in patients with SARS-CoV-2 infection
There is a high incidence of acute kidney injury (AKI) in patients with the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection
Summary
Coronaviruses (CoVs), including Severe Acute Respiratory Syndrome (SARS), Middle East Respiratory Syndrome (MERS), and the novel coronavirus disease-2 (SARS-CoV-2) are a group of enveloped RNA viruses that cause a severe respiratory infection which is associated with a high mortality [1,2]. Amongst these viruses, SARS-CoV-2 is the most virulent and is spreading rapidly around the world. Co-receptors/auxiliary proteins from protease families such as TMPRSS2 (Trans Membrane Serine Protease 2) may work in collaboration with ACE2 by priming the viral S (spike) protein and facilitating the entry of SARS coronaviruses into target cells, including airway epithelia [1,2]. The endocytosed virus is transported to the early endosome, late endosome, and eventually lysosome, where it becomes activated and acquires the capability to start replication and infection [1,5,6]
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