Acute kidney injury in infants with congenital diaphragmatic hernia

Abstract

ObjectivesTo assess the incidence of acute kidney injury (AKI) in infants with congenital diaphragmatic hernia (CDH), including those who had fetoscopic endoluminal tracheal occlusion (FETO), and the effect of AKI on mortality and length of stay.Study designTen-year retrospective review of infants admitted with CDH to a tertiary perinatal centre.ResultNinety-four infants with median gestational age of 38+1 weeks were included. Fifty-nine (62.8%) infants had AKI. Compared to infants without AKI, infants with AKI, had a similar incidence of mortality (p = 0.989). In survivors, AKI was not independently associated with a longer adjusted median length of stay [23 versus 15 days (p = 0.194)]. FETO was associated with an increased risk of AKI (p = 0.005), but neither the mortality nor length of stay of FETO infants who had AKI was increased.ConclusionAKI was present in the majority of infants with CDH and most common in those who had undergone FETO.