Abstract
Acute kidney injury occurs in approximately one-quarter to one-third of patients with major burn injury. Apart from the usual suspects – such as older age, severity of burn injury, sepsis and multiple organ dysfunction – volume overload probably has an important role in the pathogenesis of acute kidney injury.
Highlights
Despite the limitation that the study by Steinvall and colleagues includes only 127 patients with major burns, the study has several strengths
Steinvall and collaborators present the third study on acute kidney injury (AKI) defined by the RIFLE classification in patients with major burn injury [1]
As the muscles are the source of creatinine, less muscle mass will result in lower serum creatinine concentrations for the same glomerular filtration rate [8]
Summary
Steinvall and collaborators present the third study on acute kidney injury (AKI) defined by the RIFLE classification in patients with major burn injury [1]. Despite the limitation that the study by Steinvall and colleagues includes only 127 patients with major burns, the study has several strengths. There was a large difference, in the incidence of AKI between the studies of Coca and colleagues and of Steinvall and colleagues (26.6% and 24.4%, respectively) compared with that of Lopes and colleagues (35.7% incidence). The study by Lopes and colleagues classifies patients according to the original RIFLE classification, on both urine output and serum creatinine concentration [6].
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