Abstract
Screening studies of the effects of acute inhalation of 2, 4, 6-trifluoro-sym-triazine, ‘(FCN)3 (also named cyanuric fluoride), and of 2, 4, 6-tris(trifluoromethyl)-sym-tria-zine, (CF3CN)3, on male albino rats are reported. Values for LC50 of 3 ppm for cyanuric fluoride and 1400 ppm for 2, 4, 6-tris-(trifluoromethyl)-sym-triazine were found. Acute dermal application studies of the same two chemicals on rabbits are also reported. The LD50 values of 100 µl/kg of body weight for cyanuric fluoride and >1000 µl/kg of body weight for (CF3CN)3 were established. The cyanuric fluoride is particularly insidious because of its high skin permeability. Data on human response to either chemical is not well documented and therefore is quite subjective. Small quantities, possibly as low as∼l to 5 ppm, of cyanuric fluoride can be detected from its pungent odor before other body senses respond. At higher levels, burning of the eyes and breathing discomfort are readily apparent.
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