Abstract
As part of an intensive Pediatric Drug Surveillance (PeDS) Program designed to identify acute adverse drug reactions among hospitalized children, 1 we review unusual reactions observed among monitored patients in detail. We report what we believe to be the first clinical evidence of hypothermia associated with atropine sulfate. Report of a Case .—A 14-year-old, 57-kg, boy was well until one month before admission, when he experienced a grand mal seizure and was treated with phenobarbital. Two weeks later, the patient had a sore throat, frontal headache, diarrhea, and a rash that spread from the extremities to the trunk. Because of these symptoms and a fever, he was seen by a physician on the day before admission and was given aspirin and acetaminophen. Laboratory studies at that time showed a WBC count of 3,900/cu mm with 23% band cells, a negative slide test for infectious mononucleosis heterophil antibodies (Monospot), and a
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