Abstract
Low doses (0.25–2.0 μg/kg) of 2-(2, 6-dichlorophenylamino)-2-imidazoline-hydrochloride were infused into the vertebral artery of anesthetized cats. A considerable, dose-dependent decrease in blood pressure developed suddenly towards the end of the infusion. The same low doses hardly affected blood pressure when given intravenously. The hypotensive effect, observed after infusion into the vertebral artery is in agreement with the presumed central mechanism of action of the drug. In most animals the infusion of 1 μg/kg 2-(2, 6-dichlorophenylamino)-2-imidazoline-hydrochloride into the verterbral artery reduced the carotid occlusion reflex considerably, probably also via a central mechanism. The chemo-receptor component of the reflex seemed to be affected more by the drug than the baroreceptor component.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
